ADME Studies-in vivo
In vivo ADMET studies are routinely performed at JOINN in rat, dog , mini-pig and NHPs for small molecular chemicals, large molecular entity and cell therapeutic and gene therapeutic candidates. All other animal species can be considered. Studies can be performed using all common routes of administration, and LC-MS/MS, RT-PCR, ELISA and radiolabeling (Iodine-125) are routinely used in these studies. In vivo ADME studies offered by JOINN include (but are not limited to):
Mass-balance Studies
sampling of urine, faeces, volatiles, cage-wash, tissues, organs and remaining carcass
suitable caging for long-term studies for rats as well as large animals using labelled and unlabelled material
including in vivo dermal absorption studies in rats
Quantitative Tissue Distribution Studies
QWBA
Traditional method：tissue dissection, total radioactivity determination, LC-MS-MS/QPCR
Biliary Excretion
species: rat
cannulation model with tail-cuff technique
Metabolite Profiling and Identification
LC-MS(n) analysis
urine/faeces/plasma/bile samples
PK/PD Modeling